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May 27 2015

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Modafinil from 1970 until Today

Provigil, Modavigil, Modiodal, Modalert, Modvigil...? - the brain boosting drug


Modafinil (chemically known as 2-[(diphenylmethyl)sulfinyl]acetamide) is a drug developed by neurophysiology medicine professor Michel Jouvet and Lafon Laboratories in France. Though normally called Modafinil, it's sold worldwide under various brandnames including Provigil (bought from UK, Croatia, Poland, Hong Kong, Italy, The philipines, Thailand, UAE), Modavigil (bought from Australia), Modiodal (purchased in France, Japan, Singapore), Modalert, Modapro, Modvigil (the 3 purchased from India), Modasomil (purchased from Switzerland), and SpierX (purchased from Malaysia).

This is a powerful stimulant that does not only improves memory, intellectual keenness, and also other mental activities, but is amazingly efficient at restoring your brains cognitive functions at times of decreased wakefulness.

The drug works by inducing your body to boost the production of monoamines, that are specific neurotransmitters. These neurotransmitters stimulate the hypothalamus, which can be accountable for producing hormones that control sleep and the circadian rhythm, among a number of other things.

Developed to treat signs and symptoms of narcolepsy (instances of uncontrollable sleep), it will help restore alertness and fight tiredness and fatigue.
Early Development

Modafinil was originally synthesized in the 1970�s in France. After studies were carried out in 1986, it was observed that does not only was this drug effective to treat narcolepsy, it also temporarily reduced the call to sleep in healthy patients.

In 1993, Lafon Laboratories leased the rights to Modafinil with a company in america called Cephalon. After Five years, it was officially Approved by the fda and sold as Provigil like a remedy against narcolepsy and osa.

In 2007, the FDA approved Armodafinil, hitherto sold as Nuvigil. Armodafinil is technically considered an enantiomer of Modafinil. Armodafinil solely contains the (R)-enatiomer, which is component of Modafinil. This new formula was marketed to offset the financial losses caused by a market soon to be flooded with cheap generic drugs, as Cephalon was looking to lose the exclusive marketing rights for Modafinil. Armodafinil ended up being to be used as a therapy for narcolepsy, shift work sleep issue, and osa.

This season, the FDA refused a request by Cephalon to showcase Nuvigil since the first pharmaceutical strategy to jet lag.
Primary Indications

Modafinil�s primary indication is good for the management of narcolepsy, however it's often prescribed for anyone with attention deficit disorder, treatment-resistant depression, other antidepressant therapies, and ms (MS). Exploratory research is also listed promising recent results for the drug�s possible benefits in remedying depressive symptoms.

Narcolepsy can be a neurological disorder that creates uncontrollable daytime sleepiness that's caused by the too little orexin peptides in the brain, which can be to blame for controlling wakefulness and sleep-suppression. Modafinil targets these orexin neurons and activates them, which in turn promotes wakefulness.

Other common illnesses and diseases it's used to treat include fibromyalgia, chronic fatigue syndrome, myotonic dystrophy, multiple sclerosis (MS), cerebral palsy, and Parkinson�s disease. - the brain boosting drug

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